Publications

Publications

  1. A bacterial host factor confines phage localization for excluding the infected compartment through cell division. Osher Pollak Fiyaksel, Somavally Pundalik Dalvi, Bing Zhou, Miriam Ravins, Bushra Shraiteh, Saurabh Bhattacharya, Saveliy Kirillov, Prabhjot Kaur, Ilan Rosenshine, Ghosal D*, Sigal Ben-Yehuda, Cell Reports, 2026, 44 (7).
  2. Architectural intelligence: toward a spatial framework for interpreting microbiome-associated human disease. H Parappalliyalil, A Padmakumar, Ghosal D, EC Reynolds. The ISME Journal, 2026, 20 (1), wrag180.
  3. Bacterial nanotubes extend from a tubeosome organelle to establish an intercellular bridge. Manas Kumar Guria, Tengfei Zhong, Amit K Baidya, Malgorzata Zuzanna Zora, Ritesh Ranjan Pal, Venkadesaperumal Gopu, Saurabh Bhattacharya, Oren Yakovian, Miriam Ravins, Ghosal D, Grant J Jensen, Ilan Rosenshine, Mohammed Kaplan, Sigal Ben-Yehuda, bioRxiv, 2026. 2026.07. 27.740770.
  4. In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS. Przemysław Dutka, Yuxi Liu, Stefano Maggi, Ghosal D, Jue Wang, Prashant P Damke, Stephen D Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P Vogel, Carrie L Shaffer, Grant J Jensen, FEBS letters. 2026 . 600 (2026) 1589–1604.
  5. Structural basis for curvature generation and functional specialization in spirochete flagella. Luca Troman, Bindusmita Paul, Jack Kim, J Christopher Fenno, M Paula Goetting-Minesky, Eric C Reynolds, Jillian F Banfield, Paul D Veith, Ghosal D*, bioRxiv 2026, 2026.02. 04.703737.
  6. Antiparallel stacking of Csu pili drives Acinetobacter baumannii 3D biofilm assembly. Henri Malmi, Natalia Pakharukova, Bindusmita Paul, Minna Tuittila, Irfan Ahmad, Stefan David Knight, Bernt Eric Uhlin, Ghosal D, Anton V Zavialov, Nature Communications. 2026, 17 (1), 2508.
  7. A Novel Pilus System in Candidate Phyla Radiation Bacteria. Luca Troman, Junhyeong Kim, Jayson JA Rose, Matthew Johnson, Jillian F Banfield, Steve Petrovski, Ghosal D* bioRxiv. 2026 2026.03. 03.709456.
  8. An Asgard archaeon from a modern analog of ancient microbial mats. Stephanie-Jane Nobs, Matthew D Johnson, Timothy J Williams, Julia Meltzer, Xabier Vázquez-Campos, Fraser I MacLeod, Keiran Rowell, Miranda Pitt, Bindusmita Paul, Doulin C Shepherd, Katharine A Michie, Iain G Duggin, Ghosal D*, Brendan P Burns, Current Biology. 2026 . 36 (8), 2090-2103. e7.
  9. A Tripartite Co-culture System Reveals Defensive Mutualism Between a Nanobdellati Symbiont and Its Host. Hiroyuki D Sakai, Sabine Schwarzer, Satoshi Nakagawa, Milad Reyhani, Shigeru Shimamura, Matthew D Johnson, Yuya Tsukamoto, Michiru Shimizu, Ken Takai, Takuro Nunoura, Norio Kurosawa, Moriya Ohkuma, Thomas Hackl, Ghosal D, Tessa Quax, bioRxiv. 2026.06. 04.730037.
  10. Aerobic soil bacteria adapt to hypoxia by hybridizing fermentation with carbon storage. David L Gillett, Thilini Koralegedara, Tess F Hutchinson, Thanh Nguyen-Dinh, Thomas D Watts, Jessica Solari, Manasi Mudaliyar, William J Jowsey, Nadeesha Athukorala, Wei Wen Wong, Jake US Locop, Ning Hall, Luis Jimenez, Iresha Hanchapola, Han-Chung Lee, Erwin Tanuwidjaya, Joel R Steele, Ralf B Schittenhelm, Christopher K Barlow, Rhys Grinter, Gregory M Cook, Matthew B McNeil, Ghosal D, Pok Man Leung, Perran LM Cook, Chris Greening, Proceedings of the National Academy of Sciences. 2026 123 (23), e2606389123.
  11. L-type pyocins inhibit the BAM complex to kill without cell entry. Fabian Munder, Matthew D Johnson, Imogen Samuels, Laura McCaughey, Oleksii Zdorevskyi, Chunxiao Wang, Ashleigh Kropp, Lauren Zavan, Erin P Price, Derek S Sarovich, Swati Varshney, Christopher A McDevitt, Hari Venugopal, Vivek Sharma, Matthew T Doyle, Francesca Short, Ghosal D, James PR Connolly, Gavin J Knott, Rhys Grinter. Nature Communications .2026; 17, 8223.
  12. Metabolic reprogramming enables transient survival and envelope remodelling in Staphylococcus aureus under dalbavancin treatment. Maytham Hussein, Stephanie L. Neville, Jinxin Zhao, Ian R. Monk, Jonathan Wilksch, Simon Crawford, Manasi Mudaliyar, Ghosal D, Zhi Ying Kho, Xinpeng Yao, Timothy P. Stinear, Christopher A. McDevitt, Benjamin P. Howden, Jian Li, Tony Velkov,npj Antimicrobials and Resistance.https://doi.org/10.1038/s44259-026-00259-8.
  13. Viruses, Proviruses and Satellites from Asgard Archaea Enrichments Reveal Complex Microbial Interactions. Julia Meltzer, Xabier Vazquez-Campos, Matthew D Johnson, Thomas Litfin, Veronika Valova, Daniel Luque, Marily-Calyope Syrmalis, Kieran Rowell, Liam Hewitt, Katharine A Michie, Bindusmita Paul, Miranda E Pitt, Ghosal D, Belinda Carlene Ferrari, Brendan Paul Burns, bioRxiv. 2026;2026.08. 12.739948.
  14. Large attachment organelle mediates interaction between Nanobdellota archaeon YN1 and its host. MD Johnson, HD Sakai, B Paul, T Nunoura, S Dalvi, M Mudaliyar, DC Shepherd, M Shimizu, S Udupa, M Ohkuma, N Kurosawa, Ghosal D*.ISME Journal. 2025; 18(1): wrae154.
  15. Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes. Dhana G Gorasia, Eric Hanssen, Manasi Mudaliyar, Craig J Morton, Sepideh Valimehr, Christine Seers, Lianyi Zhang, Matthew T Doyle, Ghosal D, Paul D Veith, Eric C Reynolds. Nat Commun. 2025;16(1):7735.
  16. An Asgard archaeon from a modern analog of ancient microbial mats. Stephanie-Jane Nobs, Matthew D Johnson, Timothy J Williams, Julia Meltzer, Xabier Vázquez-Campos, Fraser I MacLeod, Keiran Rowell, Miranda Pitt, Bindusmita Paul, Doulin C Shepherd, Katharine A Michie, Iain G Duggin, Ghosal D*, Brendan P Burns. bioRxiv. 2025;2025.07.22.663070.
  17. A bacterial host factor confines phage localization for excluding the infected compartment through cell division. Osher Pollak Fiyaksel, Somavally Pundalik Dalvi, Bing Zhou, Miriam Ravins, Bushra Shraiteh, Saurabh Bhattacharya, Saveliy Kirillov, Prabhjot Kaur, Ilan Rosenshine, Ghosal D*, Sigal Ben-Yehuda. Cell Reports 2025;44(7).
  18. Mutational analysis of the F plasmid partitioning protein ParA reveals residues required for oligomerization and plasmid maintenance. N Mitra, D Mishra, M Mudaliyar, R Yadav, S Zinjurte, IA Puthethu, Pananghat Gayathri, Ghosal D, Ramanujam Srinivasan. Nucleic Acids Res. 2025;53(12):gkaf537.
  19. Large attachment organelle mediates interaction between Nanobdellota archaeon YN1 and its host. MD Johnson, HD Sakai, B Paul, T Nunoura, S Dalvi, M Mudaliyar, DC Shepherd, M Shimizu, S Udupa, M Ohkuma, N Kurosawa, Ghosal D*.ISME Journal. 2025; 18(1): wrae154.
  20. C-terminal glycosylation of type IX secretion system cargo proteins in Prevotella intermedia with both short and long secretion signals. Ye X, Bin Rustam N, Gorasia D, Reynolds E, Ghosal D, Veith P. Open Biol. 2025 Mar;15(3):240335.
  21. Mutations in Gordonia amarae mycolic acid biosynthetic pathway confer resistance to Patescibacteria parasite Mycosynbacter amalyticus. Rose JJA, Johnson MD, Reyhani M, Batinovic S, Seviour RJ, Ghosal D*, Petrovski S. Nat Commun. 2025 Mar 5;16(1):2202.
  22. DPANN symbiont of Haloferax volcanii accelerates xylan degradation by the non-host haloarchaeon Halorhabdus sp. Reva ON, La Cono V, Marturano L, Crisafi F, Smedile F, Mudaliyar M, Ghosal D, Selivanova EA, Ignatenko ME, Ferrer M, Fernandez-Lopez L, Krupovic M, Yakimov MM. iScience. 2025 Jan 4;28(2):111749.
  23. Membrane association and polar localization of the Legionella pneumophila T4SS DotO ATPase mediated by two nonredundant receptors. Vijayrajratnam S, Milek S, Maggi S, Ashen K, Ferrell M, Hasanovic A, Holgerson A, Kannaiah S, Singh M, Ghosal D, Jensen GJ, Vogel JP. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2401897121.
  24. Cell-to-cell interactions revealed by cryo-tomography of a DPANN co-culture system. Johnson MD, Shepherd DC, Sakai HD, Mudaliyar M, Pandurangan AP, Short FL, Veith PD, Scott NE, Kurosawa N, Ghosal D*. Nat Commun. 2024 Aug 16;15(1):7066.
  25. Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion. Liang LY, Geoghegan ND, Mlodzianoski M, Leis A, Whitehead LW, Surudoi MG, Young SN, Janes P, Shepherd D, Ghosal D, Rogers KL, Murphy JM, Lucet IS. Commun Biol. 2024 Apr 16;7(1):461.
  26. Interplay of intracellular and trans-cellular DNA methylation in natural archaeal consortia. Reva ON, La Cono V, Crisafi F, Smedile F, Mudaliyar M, Ghosal D, Giuliano L, Krupovic M, Yakimov MM. Environ Microbiol Rep. 2024 Apr;16(2):e13258.
  27. Staphylococcus epidermidis bacteriocin A37 kills natural competitors with a unique mechanism of action. Puls JS, Winnerling B, Power JJ, Krüger AM, Brajtenbach D, Johnson M, Bilici K, Camus L, Fließwasser T, Schneider T, Sahl HG, Ghosal D, Kubitscheck U, Heilbronner S, Grein F. ISME J. 2024 Jan 8;18(1):wrae044.
  28. Ultrastructural and glycoproteomic characterization of Prevotella intermedia. Ye X, Paul B, Mo J, Reynolds EC, Ghosal D*, Veith PD. MicrobiologyOpen. 2024 Apr;13(2):e1401.
  29. Structural Insights into SARS-CoV-2 Nonstructural Protein 1 Interaction with Human Cyclophilin and FKBP1. Vankadari N, Ghosal D*. J Phys Chem Lett. 2024 Feb 1;15(4):919-924.
  30. Morphological remodeling of Coxiella burnetii during its biphasic developmental cycle revealed by cryo-electron tomography. Shepherd DC, Kaplan M, Vankadari N, Kim KW, Larson CL, Dutka P, Beare PA, Krzymowski E, Heinzen RA, Jensen GJ, Ghosal D*. iScience. 2023 Jun 24;26(7):107210.
  31. Structure and Function of the Dot/Icm T4SS. Dutka P, Liu Y, Maggi S, Ghosal D, Wang J, Carter SD, Zhao W, Vijayrajratnam S, Vogel JP, Jensen GJ. bioRxiv [Preprint]. 2023 Mar 22.
  32. Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly. Kreida S, Narita A, Johnson MD, Tocheva EI, Das A, Ghosal D*, Jensen GJ. Structure. 2023 Apr 6;31(4):385-394.e4.
  33. Manipulation of epithelial cell architecture by the bacterial pathogens Listeria and Shigella. Hartland EL, Ghosal D, Giogha C. Curr Opin Cell Biol. 2022 Dec;79:102131.
  34. Discovery of a Novel Inner Membrane-Associated Bacterial Structure Related to the Flagellar Type III Secretion System. Kaplan M, Oikonomou CM, Wood CR, Chreifi G, Ghosal D, Dobro MJ, Yao Q, Pal RR, Baidya AK, Liu Y, Maggi S, McDowall AW, Ben-Yehuda S, Rosenshine I, Briegel A, Beeby M, Chang YW, Shaffer CL, Jensen GJ. J Bacteriol. 2022 Aug 16;204(8):e0014422.
  35. Archaic chaperone-usher pili self-secrete into superelastic zigzag springs. Pakharukova N, Malmi H, Tuittila M, Dahlberg T, Ghosal D, Chang YW, Myint SL, Paavilainen S, Knight SD, Lamminmäki U, Uhlin BE, Andersson M, Jensen G, Zavialov AV. Nature. 2022 Sep;609(7926):335-340.
  36. Structure of Human TMPRSS2 in Complex with SARS-CoV-2 Spike Glycoprotein and Implications for Potential Therapeutics. Vankadari N, Ketavarapu V, Mitnala S, Vishnubotla R, Reddy DN, Ghosal D*. J Phys Chem Lett. 2022 Jun 8:5324-5333.
  37. Three-dimensional insights into human enveloped viruses in vitro and in situ. Vankadari N, Shepherd DC, Carter SD, Ghosal D*. Biochem Soc Trans. 2022 Feb 28;50(1):95-105.
  38. From cells to atoms: Cryo-EM as an essential tool to investigate pathogen biology, host-pathogen interaction, and drug discovery. Shepherd DC, Dalvi S, Ghosal D*. Mol Microbiol. 2022 Mar;117(3):610-617.
  39. In Situ Imaging and Structure Determination of Biomolecular Complexes Using Electron Cryo-Tomography. Kaplan M, Nicolas WJ, Zhao W, Carter SD, Metskas LA, Chreifi G, Ghosal D, Jensen GJ. (2021). Methods Mol Biol. PMID: 33368000.
  40. Structure of the Bacterial Cellulose Ribbon and Its Assembly-Guiding Cytoskeleton by Electron Cryotomography. Nicolas WJ, Ghosal D*, Tocheva EI, Meyerowitz EM, Jensen GJ. (2020). J Bacteriol.Jan 11;203(3):e00371-20.
  41. In vivo structure of the Legionella type II secretion system by electron cryotomography. Ghosal D*, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ. (2019). Nature Microbiology. 4, 2101–2108 (2019).
  42. Molecular architecture, polar targeting and biogenesis of the Legionella Dot/Icm T4SS. Ghosal D*, Jeong KC, Chang YW, Gyore J, Teng L, Gardner A, Vogel JP, Jensen GJ. (2019). Nature Microbiology. Jul;4(7):1173-1182.
  43. The presence and absence of periplasmic rings in bacterial flagellar motors correlates with stator type. Kaplan M, Ghosal D*, Subramanian P, Oikonomou C, Kjær A, Pirbadian S, Ortega DR, El-Naggar MY, Jensen GJ. (2019). eLife. https://doi.org/10.7554/eLife.43487.
  44. In Situ Imaging and Structure Determination of Bacterial Toxin Delivery Systems Using Electron Cryotomography. Ghosal D*, Kaplan M, Chang YW, Jensen GJ. (2019). Methods Mol Biol.
  45. In situ imaging of the bacterial flagellar motor disassembly and assembly processes. Kaplan M, Subramanian P, Ghosal D*, Oikonomou C, Pirbadian S, Starwalt‐Lee R, Mageswaran S, Ortega DR, Gralnick JA, El-Naggar MY, Jensen GJ. (2019). EMBO J. 2019:1921:249-265.
  46. In vivo structures of the Helicobacter pylori Cag type IV secretion system. Shaffer CL*, Chang YW*, Rettberg L, Ghosal D*, Jensen GJ. (2018). Cell Rep. Apr 17;23(3):673-681.
  47. In situ structure of the Legionella Dot/Icm type IV secretion system by electron cryotomography. Ghosal D*, Chang YW, Jeong KC, Vogel JP, Jensen GJ. (2017). EMBO Rep. May;18(5):726-732
  48. Polar delivery of Legionella type IV secretion system substrates is essential for virulence. Jeong KC, Ghosal D*, Chang YW, Jensen GJ, Vogel JP. (2017). PNAS. 114 (30) 8077-8082.
  49. Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis. Yao Q, Jewett AI, Chang YW, Oikonomou CM, Beeby M, Iancu CV, Briegel A, Ghosal D, Jensen GJ. (2017). EMBO J. 36, 10 (2017).
  50. Morphology of the archaellar motor and associated cytoplasmic cone in Thermococcus kodakaraensis. Briegel A, Oikonomou CM, Chang YW, Kjær A, Huang AN, Kim KW, Ghosal D, Nguyen HH, Kenny D, Ogorzalek Loo RR, Gunsalus RP, Jensen GJ. (2017). EMBO Rep.Sep;18(9):1660-1670.
  51. The C-terminal tails of heterotrimeric kinesin-2 motor subunits directly bind to α-tubulin1. Girotra M, Srivastava S, Kulkarni A, Barbora A, Bobra K, Ghosal D, Devan P, Aher A, Jain A, Panda D, Ray K. (2017). Traffic.Feb;18(2):123-133.
  52. Collaborative protein filaments. Ghosal D, Löwe J. (2015). EMBO J. Sep 14;34(18):2312-20.
  53. MinCD cell division proteins form alternating copolymeric cytomotive filaments. Ghosal D*, Trambaiolo D, Amos LA, Löwe J. (2014). Nature Communications. PMCID: PMC4338524.
  54. Interaction with a kinesin-2 tail propels choline acetyltransferase flow towards synapse. Sadananda A, Hamid R, Doodhi H, Ghosal D, Girotra M, Jana SC, Ray K. (2012). Traffic. Jul;13(7):979-91.
  55. KAP, the accessory subunit of kinesin-2, binds the predicted coiled-coil stalk of the motor subunits. Doodhi H*, Ghosal D, Krishnamurthy M, Jana SC, Shamala D, Bhaduri A, Sowdhamini R, Ray K. (2009). Biochemistry. Mar 17;48(10):2248-60.

Book Chapters

  1. FtsZ-ring Architecture and Its Control by MinCD. Szwedziak P†, Ghosal D† (2017) Subcell Biochem.
  2. Bacterial and Archaeal Cytoskeletons. Ghosal D†, Löwe J, Amos L. A. (2016) Encyclopedia of Cell Biology.
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