We are developing next-generation approaches to in situ structural biology by integrating cryo-electron tomography (cryo-ET), cryo-FIB lift-out, montage tomography, and advanced high-resolution cryo-CLEM with innovative sample preparation, large-volume imaging, and AI-aided data processing. We are designing new workflows specifically to understand how pathogenic bacteria and viruses cause infectious disease at  molecular resolution.

We are also harnessing AI to accelerate data acquisition, increase imaging throughput, improve resolution, and enable rapid interpretation of complex cellular datasets. Together, these technologies have the potential to transform how we investigate molecular mechanisms in their native environments, enabling structural biology across scales, from individual molecular machines to entire cells, tissues, and microbial communities.